FASEB journal : official publication of the Federation of American Societies for Experimental BiologyNF-E2-Related Factor 2AnimalsFerroptosisDoxorubicinMice
The FAK-NRF2 Axis Alleviates DOX-Induced Cardiotoxicity by Inhibiting Ferroptosis.
Ying Zhao, Mo Chen, Linghui Kong, Shufei Wu, Cheng Teng, Song Hu, Kangjie Xie, Jiankui Du, Xiaoyan Zhu, Pengxiang Wang, Pingbo Xu
Published: 202510.1096/fj.202501368R
Abstract
Doxorubicin (DOX), a prevalent anthracycline chemotherapeutic agent, is associated with considerable cardiotoxicity, the molecular mechanisms of which remain incompletely understood. Focal adhesion kinase (FAK), a non-receptor protein tyrosine kinase…
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