FASEB journal : official publication of the Federation of American Societies for Experimental BiologyMesenchymal Stem CellsOsteogenesisCellular SenescenceProto-Oncogene Proteins c-aktReceptors
Mechanical Stretch Prevents Senescence-Associated Osteogenic Impairment in Mesenchymal Stem Cells via CXCR4/PI3K/AKT Signaling.
Jia Yi Chen, Ting Jiang, Yan Ting Xu, Zi An Li, Ning Juan Ouyang, Guo Hua Tang
Published: 202510.1096/fj.202500239R
Abstract
The reduced osteogenic differentiation of senescent mesenchymal stem cells (MSCs) contributes to impaired bone formation and limits their therapeutic potential in bone regeneration. CXCR4 has been implicated in both MSC aging and osteogenesis. Mechan…
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