Toxicological sciences : an official journal of the Society of Toxicology
Computational Integration of In Vivo Single Cell and In Vitro Bulk Transcriptomics Across 236 Human and Mouse Datasets Differentiates Physiological versus Non-Physiological Hepatic Cell Lines for Hepatotoxicity Screening.
Thomas Kowal, Susanna Wang, Michael Cheng, Ruoshui Liu, Montgomery Blencowe, Xia Yang
Published: 202510.1093/toxsci/kfaf171
Abstract
New approach methods (NAMs), including in vitro paradigms, are needed to increase throughput, sustainability, and ethicality in toxicity research. However, selecting optimal cell culture models that mimic in vivo physiological conditions is challengi…
Preview only. Read the full abstract at the source