Rheumatology (Oxford, England)
Single-cell transcriptome-wide Mendelian randomization and colocalization reveal cell-specific mechanisms in systemic lupus erythematosus.
Yanggang Hong, Jiani Ye, Chunyan Hua
Published: 202510.1093/rheumatology/keaf606
Abstract
OBJECTIVE: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex genetic architecture and immune cell involvement. While genome-wide association studies (GWAS) have identified numerous risk loci, most are non-coding,…
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