Protein engineering, design & selection : PEDS
VIF-Ig: A novel Fc framework for ADCC by incorporation of VHH unit.
Yaohui Li, Yichen Huang, Yingdan Duan, He Zhao, Shanshan Wang, Jiefu Li, Hua Jing, Kebing Yu, Chih-Chuan Chang, Feng Wang
Published: 202610.1093/protein/gzag003
Abstract
Antibody-dependent cellular cytotoxicity is a key mechanism for antibody-based therapeutics, and current engineering strategies to enhance ADCC primarily rely on two approaches: Fc mutations to improve the antibody's intrinsic CD16a affinity, or the…
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