The Plant cell
Sec62 restricts ER-replicating positive-strand RNA virus infections via UPR-dependent ER-phagy.
Ruiqi Wang, Qianshen Zhang, Lifan Zhou, Dingliang Zhang, Yiping Wang, Xinyu Zhang, Xiuling Cao, Chenchen Zhong, Xiaofei Zhao, Meng Yang, Dawei Li, Xiaofeng Wang, Yongliang Zhang
Published: 202610.1093/plcell/koag014
Abstract
Positive-strand RNA [(+)RNA] viruses induce endomembrane remodeling to form viral replication organelles (VROs), which disrupt organelle homeostasis. How hosts restore organelle homeostasis and how these responses influence viral replication remain e…
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