The oncologist
Phase I Study of Bevacizumab and Temsirolimus Combination Therapy in Advanced Malignancies: Safety, Efficacy, and Ovarian Cancer Expansion.
Sarina A Piha-Paul, Chieh Tseng, Emily Thompson, R Jason Stafford, Hung Le, Lei Kang, Siqing Fu, Apostolia Tsimberidou, George Blumenschein, Jordi Rodon Ahnert, John M Slopis, David Hong, Aung Niang, Funda Meric-Bernstam, Chaan S Ng
Published: 202510.1093/oncolo/oyaf413
Abstract
BACKGROUND: Bevacizumab and temsirolimus target angiogenic and mTOR pathways in cancer progression. METHODS: This phase I study enrolled 48 heavily pretreated patients with advanced solid tumors, including an ovarian cancer expansion cohort. Patients…
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