Neuro-oncology
KMT2A is a prerequisite of malignant transformation during IDH-mutant gliomagenesis.
Marilin S Koch, Minh Deo, Claudia Schmidt, Adrianna Podolak, Julian Taranda, Michael S Hoetker, Şevin Turcan
Published: 202610.1093/neuonc/noag006
Abstract
BACKGROUND: IDH1R132H is the defining mutation of low-grade gliomas (LGGs), inflicting broad epigenetic rewiring that leads to malignant transformation. Recent studies demonstrated that cell fate change from astrocyte to LGG is accompanied by redistr…
Preview only. Read the full abstract at the source