Neuro-oncology
MBD3 deficiency decommissions the NuRD complex and orchestrates the epigenetic regulation of gene expression to suppress neuroblastoma progression.
Chen Chen, Bize Guo, Siyan Wu, Qinfang Zhu, Hui Shi, Jinhu Wang, Qiang Shu, Ting Tao
Published: 202610.1093/neuonc/noaf297
Abstract
BACKGROUND: Neuroblastoma (NB) is the most common extracranial solid tumor in children and accounts for 15% of childhood cancer death. The nucleosome remodeling and deacetylase (NuRD) complex is a major chromatin remodeling complex that regulates chr…
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