Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Telitacicept targets Gd-IgA1 and autoantibody-producing B cells in IgA nephropathy.
Qinjie Weng, Xinyi Zhu, Hong Ren, Xiao Li, Jingyuan Xie
Published: 202610.1093/ndt/gfag001
Abstract
IgA nephropathy (IgAN) is the most common primary glomerulonephritis and a leading cause of end-stage renal disease (ESRD) for young adults. The key pathogenesis of IgAN involves overproduction of galactose-deficient IgA1 (Gd-IgA1) and anti-Gd-IgA1 a…
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