Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
RNA interference medication and transplantation procedures in patients with primary hyperoxaluria type 1 (PH1).
Cristina Martin-Higueras, Lodovica Borghese, Jens König, Caroline Kempf, Britta Höcker, Henry Fehrenbach, Adam Walli, Mark Born, Katharina Linden, Bernd Hoppe
Published: 202510.1093/ndt/gfaf202
Abstract
BACKGROUND AND HYPOTHESIS: Defective hepatic alanine-glyoxylate aminotransferase (AGT) leads to oxalate overproduction in primary hyperoxaluria type 1 (PH1). Nedosiran and lumasiran are RNA interference (RNAi) agents inhibiting oxalate production. In…
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