Nucleic acids researchHumansOxidation-ReductionZinc FingersTumor Suppressor ProteinsProtein Binding
Novel intermolecular zinc fingers and redox-driven conformational changes dictate tumor suppressor ZMYND11's role in cooperative recognition of diverse targets.
Xuehui Bai, Jiatai Zhang, Shiyang Wang, Keyang Huang, Ziyang Pan, Ailing Liang, Wei Wu, Zhengquan Yu, Yiyun Chen, Yufeng Tong, Shaodong Dai, Zhongzhou Chen
Published: 202610.1093/nar/gkag048
Abstract
The zinc finger-myeloid-Nervy-DEAF-1 (ZMYND) protein family is associated with embryonic development and cancer regulation. Specifically, the tumor suppressor ZMYND11 is downregulated in multiple malignancies. Here, we identified an inhibitory role o…
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