The Journal of pharmacy and pharmacology
Characterizing resistance in prostate cancer at a single cell level with hormonal treatment and epigenetic inhibitors.
Morgan Howells, Priyadarsini Gangadharannambiar, Calum McMullen, Francesco Crea, Wendi Bacon, Colette Christiansen
Published: 202510.1093/jpp/rgaf100
Abstract
BACKGROUND: Late-stage prostate cancer is treated with hormonal therapy. While initially effective, development of drug resistance is common. Hypoxia, a local-environmental occurrence in tumours, is known to trigger hormone-independence and concurren…
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