The Journal of pharmacy and pharmacology
Human epidermal growth factor receptor 2 as a target of 1,2,3,4,6-penta-O-galloyl-β-d-glucose in colon cancer.
Huihai Yang, Grace Gar-Lee Yue, Ping-Chung Leung, Chun-Kwok Wong, Ying-Jun Zhang, Clara Bik-San Lau
Published: 202510.1093/jpp/rgaf098
Abstract
OBJECTIVES: Although HER2 overexpression is observed in only 2%-3% of colorectal cancer (CRC) patients, its amplification can function as a compensatory mechanism that drives CRC resistance to targeted therapy. 1,2,3,4,6-Penta-O-galloyl-β-d-glucose (…
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