Journal of neuropathology and experimental neurology
Deposition of aggregated cystatin C-amyloid-β complexes and reduced cathepsin B activity modulate cerebral amyloid angiopathy pathogenesis.
Jubo Bhuiya, Abu Zaffar Shibly, Abdullah Md Sheikh, Shatera Tabassum, Fatema Binte Abdullah, Jerin Fahmida, Hiro Tamegai, Shun Aritake, Shozo Yano, Atsushi Nagai
Published: 202510.1093/jnen/nlaf138
Abstract
Cystatin C (CST3) colocalizes with amyloid-β (Aβ) around vessels in cerebral amyloid angiopathy (CAA). This study aimed to characterize CST3-Aβ interactions in CAA. Brain tissues from 12 Alzheimer disease (AD) and 5 non-AD control subjects, along wit…
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