Journal of neuropathology and experimental neurology
Systemic microbial antigen administration ameliorates experimental autoimmune encephalomyelitis via MHC-II downregulation in the CNS and secondary lymphoid organs.
Marina Boziki, Paschalis Theotokis, Evangelia Kesidou, Eleni Karafoulidou, Ilias Salamotas, Anastasia Chatziefstratiadou, Olga Touloumi, Konstantinos Papadakos, Dionyssios Sgouras, Ofira Einstein, Jannis Kountouras, Nikolaos Grigoriadis
Published: 202510.1093/jnen/nlaf126
Abstract
Microbial stimuli modulate CNS neuroinflammation but the exact molecular mechanisms are largely unknown. In this study, we aimed to delineate the effect of systemic pre-disease microbial antigen administration of 2 different microbial strains on syst…
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