Journal of the National Cancer Institute
NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer.
Dylan Williams, Chandni Patel, Kate Murray, Lucy Oldfield, Benjamin Small, Lawrence N Barrera, Rachel O'Sullivan, James Birch-Ford, Anthony Evans, Fiona Campbell, Pedro A Perez-Mancera, Christopher M Halloran, Daniel Palmer, William Greenhalf, Ian M Copple
Published: 202510.1093/jnci/djaf345
Abstract
BACKGROUND: NAD(P)H Quinone Dehydrogenase 1 (NQO1), a detoxification enzyme regulated by the Nrf2 cytoprotective pathway, is overexpressed in pancreatic ductal adenocarcinoma (PDAC). NQO1 levels are also influenced by the C609T single nucleotide poly…
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