Pathogenic Mechanism Underlying Parkinsonism Induced by Neurotoxicants (MPTP and 6-Hydroxydopamine) and α-Synuclein: A Unifying Hypothesis.

The mechanism underlying the selective loss of dopaminergic neurons in Parkinson's disease (PD) is still not understood at present. MPTP, an illicit drug contaminant, can selectively induce parkinsonism in humans and animals which is very similar to…

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