Journal of immunology (Baltimore, Md. : 1950)
Grass carp (Ctenopharyngodon idella) SMYD3 negatively regulates antiviral innate immunity by methylating IRF3 and IRF7 during GCRV infection.
Zixuan Wang, Yao Bai, Wen Liu, Chunchun Zhu, Xueyi Sun, Hongyan Deng, Shuai Shi, Wuhan Xiao, Xing Liu
Published: 202510.1093/jimmun/vkaf311
Abstract
Interferon regulatory factors 3 and 7 (IRF3 and IRF7, respectively), which serve as key transcription factors in interferon (IFN) activation, are tightly regulated by a variety of mechanisms, including multiple posttranslational modifications, to ful…
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