Journal of immunology (Baltimore, Md. : 1950)
Leveraging optimized oligonucleotide-tagged antigen assemblies and single-cell sequencing for multiplexed proteogenomic profiling of human B cell reactivities.
Richard Apps, Jessie J Polanco, Kelsey E Lowman, Liya Wang, Foo Cheung, Aparna Kotekar, Galina Koroleva, Amrita Mukherjee, Michelle Ylade, Maria V Crisostomo, Jedas V Daag, Kristal-An Agrupis, Jacqueline Deen, Krista Gangler, Jeffrey Cohen
Published: 202510.1093/jimmun/vkaf301
Abstract
Antigen-specific responses to complex antigens encompass a range of cell states and reactivities to an array of epitopes, reflective of the heterogeneity in immune responses. Single-cell sequencing has created new opportunities when combined with flo…
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