Journal of immunology (Baltimore, Md. : 1950)
Progenitor effects and unique transcriptomic signatures linked to differentiation phenotype in clonally expanded antigen-specific CD8 T memory stem cells.
Yanran Zhao, Jerome Samir, Elizabeth Keoshkerian, Hui Li, Hongyan An, Rowena A Bull, Fabio Luciani, Andrew R Lloyd
Published: 202510.1093/jimmun/vkaf299
Abstract
Memory stem CD8+ T cells (TSCM) are a long-lived T-cell subset with stem cell-like properties, playing a key role in antiviral immunity. Despite their importance, comprehensive single-cell transcriptomic profiling of antigen-specific TSCM has not bee…
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