Journal of immunology (Baltimore, Md. : 1950)
Relationship among Toll-like receptors, β2 adrenergic receptor, and mitogen-activated protein kinases in regulating Il1b transcription.
Filipe M de Melo, Juliana T Maricato, Beatriz M Freire, Rafael Q de Souza, An-Chieh Feng, Paulo César F Dos Santos, Karina R Bortoluci, Pedro M Moraes-Vieira, Philip O Scumpia, Stephen T Smale, Alexandre S Basso
Published: 202510.1093/jimmun/vkaf285
Abstract
The β2-adrenergic receptor (β2AR) signaling suppresses the activation of key inflammatory genes in Toll-like receptor (TLR) stimulated macrophages, but Il1b transcription is activated by β2AR signaling. The β2ARs potently activate protein kinase A an…
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