Journal of immunology (Baltimore, Md. : 1950)
NLRC4 deficiency improves host protection during sepsis by regulating macrophage and T-cell responses.
Sagar Paudel, Laxman Ghimire, Duane Jeansonne, Shanshan Cai, Dinesh Bhattarai, John Le, Christopher Taylor, Samithamby Jeyaseelan
Published: 202510.1093/jimmun/vkaf272
Abstract
Sepsis followed by multiple organ failure is a leading cause of death in noncoronary intensive care units. While the NLRC4 inflammasome has been shown to play a crucial role in the innate immune response, the role of NLRC4 in sepsis remains unclear.…
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