Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
IRE1 signaling in osteoprogenitors augments β-catenin activity and physiologic bone accrual.
Lakshmi D Kolora, Christian Melendez-Suchi, Veronica Butler, Li Han, Maria Almeida, Kartik Shankar, Douglas J Adams, Srividhya Iyer
Published: 202610.1093/jbmr/zjag001
Abstract
The endoplasmic reticulum (ER) orchestrates the folding of the large amounts of membrane and secretory proteins that are synthesized during the process of osteogenesis. The Unfolded Protein Response (UPR) resulting from accumulation of misfolded prot…
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