Journal of animal science
A conserved functional missense SNP (E100K) in sheep MC4R gene leading to functional loss and impacting the growth traits.
Yuta Yang, Peiyao Liu, Taotao Yan, Xiangding Wang, Qian Zhou, Yang Li, Ran Li, Qingfeng Zhang, Chuanying Pan, Xianyong Lan
Published: 202610.1093/jas/skag011
Abstract
The Melanocortin-4 receptor (MC4R), a key regulator of energy balance and feeding behavior, plays a critical role in sheep growth. Herein, we identified a naturally occurring conserved functional SNP (g.59480661G > A, E100K, P.Glu100Lys) in the sheep…
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