Journal of the American Medical Informatics Association : JAMIA
Scalable confounding adjustment in real-world evidence: benchmarking data-adaptive and investigator-specified strategies in a large-scale trial emulation study.
Andrew R Weckstein, Shirley V Wang, Richard Wyss, Sebastian Schneeweiss
Published: 202510.1093/jamia/ocaf204
Abstract
OBJECTIVES: Real-world evidence (RWE) increasingly informs clinical decisions, yet manual adjustment for confounding limits scalability. Data-adaptive (DA) algorithms for high-dimensional proxy adjustment show promise but have not been systematically…
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