International immunology
Repeated mRNA vaccination and breakthrough infection reveal durable dominance but diminishing recall of vaccine-induced CD8⁺ T-cell clones.
Peng Xu, Satoshi Ueha, Hiroyasu Aoki, Masahiro Kitabatake, Chen Mingyu, Shigeyuki Shichino, Atsushi Hara, Noriko Ouji-Sageshima, Toshihiro Ito, Chihiro Motozono, Kouji Matsushima
Published: 202610.1093/intimm/dxag004
Abstract
Successive mRNA vaccinations preserve SARS-CoV-2-specific T-cell immunity, but how individual CD8⁺ T-cell clones behave across repeated booster doses and breakthrough infection (BTI) remains poorly defined. We longitudinally tracked bulk CD8⁺ TCRβ re…
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