International immunology
TLR7 responses to nucleosides drive sialadenitis in Slc29a3-deficient mice.
Takuma Shibata, Kotono Okabe-Kibe, Hu Chen, Kiyoshi Yamaguchi, Daisuke Koga, Masato Taoka, Yuji Motoi, Ryota Sato, Hao-Wen Hsiao, Ryutaro Fukui, Naoki Kaneko, Zhiqin Wang, Yanmei Li, Wei Wei, Zhigang Cai
Published: 202510.1093/intimm/dxaf073
Abstract
Autoimmune sialadenitis is a hallmark of IgG4-related disease (IgG4-RD) and Sjögren syndrome (SS). The single-stranded RNA sensor TLR7 has been shown as a driver of sialadenitis. Although TLR7 is activated by ssRNA degradation products such as nucleo…
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