The Journal of infectious diseases
Maternal-Fetal Letermovir Exposure in Vivo and PBPK-based: A Rationale for Congenital CMV Therapy.
Valentine Faure Bardon, Naim Bouazza, Gilles Peytavin, Minh Patrick Le, Sihem Benaboud, Frantz Foissac, Gabrielle Lui, Léo Froelicher-Bournaud, Saïk Urien, Bettina Bessieres, Tiffany Guilleminot, Laurence Bussieres, Jean-Marc Treluyer, Marianne Leruez-Ville, Yves Ville
Published: 202510.1093/infdis/jiaf619
Abstract
BACKGROUND: Cytomegalovirus (CMV) affects 0.5-2.0% of all live births and is the main nongenetic cause of congenital sensorineural hearing loss and neurological damage, yet no validated prenatal treatment exists for infected fetuses. Letermovir, a CM…
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