The Journal of infectious diseases
Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam against Metallo-β-Lactamase-Producing Carbapenem-Resistant Acinetobacter baumannii: A Genomics-Informed Mechanism-Based Model.
Bhavatharini Arun, Eloise Liu, Quentin Vallé, Rajnikant Sharma, Ngoc Minh Bui, Vyanka Mezcord, Irene Luu, German Matias Traglia, Fernando Pasteran, David Paterson, Robert A Bonomo, María Soledad Ramirez, Gauri G Rao
Published: 202510.1093/infdis/jiaf567
Abstract
BACKGROUND: Carbapenem-resistant Acinetobacter baumannii (CRAB) infections, driven by metallo- and class D serine β-lactamases, pose significant therapeutic challenges. β-lactam-based combinations offer a promising alternative to agents like colistin…
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