Inflammatory bowel diseases
Biopsy-derived colonoid air-liquid interface monolayers reveal persistent mucosal defects in ulcerative colitis patients.
Ashley Gilliland, Yan Chen, Irvin Ng, Xiao Han, Ho Pan Sham, Itay Kalisky, Dominique Lévesque, Kevan Jacobson, Wei Xiong, François-Michel Boisvert, Brian Bressler, Bruce A Vallance
Published: 202610.1093/ibd/izaf318
Abstract
BACKGROUND: The inflammatory bowel disease (IBD) ulcerative colitis (UC) is characterized by colonic mucosal inflammation and barrier dysfunction. We hypothesized that UC causes persistent defects in mucosal homeostasis, evident even in the absence o…
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