Human reproduction (Oxford, England)MaleHumansCystic Fibrosis Transmembrane Conductance RegulatorSperm MotilityGlycerol
A novel CFTR-AQP7 protein complex regulates glycerol transport and motility of human sperm.
João C Ribeiro, Raquel L Bernardino, Paula Jorge, Margarida Geraldo, Emília Vieira, Rosário Santos, Alberto Barros, Aminata Touré, Tarsila G Castro, Artur Cavaco-Paulo, Marco G Alves, Pedro F Oliveira
Published: 202510.1093/humrep/deaf210
Abstract
STUDY QUESTION: Does the interaction between CFTR and AQP7 in human spermatozoa play a role in the molecular mechanisms underlying sperm motility? SUMMARY ANSWER: CFTR inhibition reduces sperm motility and AQP7-mediated glycerol permeability in human…
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