The journals of gerontology. Series A, Biological sciences and medical sciencesFemaleAnimalsOvaryMiceAging
Inhibition of the ISG15 prevents inflammation-dependent ovarian aging.
Yaru Chen, Xin Liu, Yuyang Song, Lei Wang, Shang Wu, Jiawei Zhou, Xianwen Peng, Shuqi Mei, Fenge Li
Published: 202510.1093/gerona/glaf230
Abstract
Inflammation is a hallmark of aging and negatively affects ovarian function and female fertility. ISGylation is a post-translational modification regulating many life activities, including inflammation, immunomodulation, and embryo implantation. Howe…
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