Genetics
The Ess1 prolyl isomerase represses TERRA transcription and promotes telomere replication in Saccharomyces cerevisiae.
Juxiu Chen, Lin Yang, Xiaohan Zhu, Jian Wu, Ming Lei, Zhenfang Wu
Published: 202610.1093/genetics/iyag017
Abstract
The conserved Ess1 prolyl isomerase (PIN1 in human) binds the carboxy-terminal domain (CTD) of RNA Pol II, and plays multiple roles in transcription regulation. Consistent with an essential role of the human PIN1 in telomere maintenance, previous scr…
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