Genetics
The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding 'ZZ' domain.
Timothy C H Low, Hua Luo, Chalini Weerasooriya, Zhuyi Wang, Sichun Lin, Angelo Karaiskakis, Stephane Angers, Craig A Smibert, Howard D Lipshitz
Published: 202510.1093/genetics/iyaf241
Abstract
Post-transcriptional regulation is particularly prominent during the maternal-to-zygotic transition (MZT), a developmental phase during which a large proportion of maternally provided mRNAs is repressed and cleared from metazoan embryos. RNA-binding…
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