Genome biology and evolution
Emergence and tandem repeat-mediated elongation of a translated de novo open reading frame in human oncogenic RNA gene VPS9D1-AS1 (MYU).
Lin Chou, Shu-Ting Cho, Jiwon Lee, David Laub, Douglas Meyer, Hannah Carter, Anne-Ruxandra Carvunis
Published: 202610.1093/gbe/evag005
Abstract
New protein-coding genes can arise de novo from ancestrally noncoding regions when open reading frames (ORFs) outside annotated genes are exposed to selection via pervasive translation. These ORFs are usually born short, and their elongation is consi…
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