European journal of preventive cardiology
Genetic modelling of triglyceride-rich lipoprotein/remnant lowering mimics APOC3-silencing and predicts clinically relevant coronary heart disease event reductions.
Elias Björnson, Chris Packard, Martin Adiels, Nicholas J Leeper, Jennifer Hellawell, Anders Gummesson, Steven E Nissen, Jan Borén
Published: 202510.1093/eurjpc/zwaf657
Abstract
AIMS: Triglyceride-rich lipoproteins (TRLs) and remnants are established causal risk factors for coronary heart disease (CHD). APOC3 gene-silencing agents reduce TRL/remnant concentrations but the consequent quantitative effect on CHD risk is not yet…
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