Environmental toxicology and chemistry
Integrative network-based construction of ecologically relevant computational adverse outcome pathways for organic mercury-induced toxicity.
Shreyes Rajan Madgaonkar, Nikhil Chivukula, Vasavi Garisetti, Shambanagouda Rudragouda Marigoudar, Krishna Venkatarama Sharma, Areejit Samal
Published: 202610.1093/etojnl/vgag026
Abstract
Adverse outcome pathways (AOPs) describe mechanisms of toxicity by connecting molecular events with outcomes at higher levels of biological organization. Computational AOPs (cAOPs), constructed using existing toxicological data, can accelerate the ea…
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