European journal of endocrinologyAnimalsDietHigh-FatMiceInbred C57BL
Inhibition of endocannabinoid synthesis enzymes DAGL and NAPE-PLD transiently lowers body weight and alters glucose homeostasis during a high-fat diet challenge in mice.
Robin van Eenige, Elena Sánchez-López, Anna T Hoekstra, Zhixiong Ying, Mariëtte R Boon, Elliot D Mock, Xinyu Di, Martin Giera, Mario van der Stelt, Patrick C N Rensen, Sander Kooijman
Published: 202510.1093/ejendo/lvaf212
Abstract
BACKGROUND: Cannabinoid receptor 1 inhibition poses an effective treatment strategy in obesity, but has a risk of psychiatric side effects. As high-fat diet (HFD)-feeding acutely increases expression of endocannabinoid synthesis enzymes and circulati…
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