Journal of Crohn's & colitisHumansCrohn DiseaseDrug RepositioningFibrosisFibroblasts
Drug repurposing approach for the discovery of therapeutic agents for Crohn's disease-associated intestinal fibrosis.
Dimitrios Nikolakis, Andrew Y F Li Yim, Kenneth L Overberg, Mohammed Ghiboub, Manon E Wildenberg, Wouter J de Jonge, Dalia Lartey, Florian Rieder, Geert R D'Haens, Marleen G H van de Sande, Mark Löwenberg
Published: 202510.1093/ecco-jcc/jjaf137
Abstract
BACKGROUND AND AIMS: Intestinal fibrosis in Crohn's disease (CD) frequently leads to stricture formation, with current treatment options limited to endoscopic balloon dilation and surgery. This underscores the urgent need for anti-fibrotic therapies.…
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