Cardiovascular research
Mitoregulin supports mitochondrial membrane integrity and protects against cardiac ischemia-reperfusion injury.
Colleen S Stein, Xiaoming Zhang, Nathan H Witmer, Edward Ross Pennington, Scott Hahn, Adam C Straub, Saame Raza Shaikh, Ryan L Boudreau
Published: 202610.1093/cvr/cvag011
Abstract
AIMS: We and others discovered a highly conserved mitochondrial transmembrane microprotein, named Mitoregulin (Mtln), that supports lipid metabolism. We reported that Mtln strongly binds cardiolipin (CL), increases mitochondrial respiration and Ca2+…
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