Cardiovascular research
Identification of rare missense variants reducing cathepsin O secretion in families with intracranial aneurysm.
Milène Freneau, Raphael Blanchet, Maxence Bodet, Sandro Benichi, Mary-Adel Mrad, Surya Prakash Rao Batta, Marc Rio, Stéphanie Bonnaud, Pierre Lindenbaum, Fabien Laporte, Stéphane Cuénot, Thibaud Quillard, Mike Maillasson, Sandrine Morel, Brenda Kwak
Published: 202610.1093/cvr/cvaf279
Abstract
AIMS: Intracranial aneurysm (IA) is a common cerebrovascular abnormality characterized by localized dilation and wall thinning in cerebral arteries, which can rupture and lead to fatal subarachnoid hemorrhage. Although genetic factors can contribute…
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