Cardiovascular research
MCPPIR promotes cardiomyocyte proliferation and cardiac repair via o8G oxidation of POC1B mRNA.
Tao Wang, Xin-Zhe Chen, Hong-Fei Xu, Jin-Xi Wang, Jia-Hao Ren, Lu-Yu Zhou, Cui-Yun Liu, Xin-Min Li, Yu-Qin Wang, Su-Min Yang, Mei-Hua Zhang, Yu-Hui Zhang, Kai-Yang Lin, Jin-Wei Tian, Kun Wang
Published: 202510.1093/cvr/cvaf265
Abstract
AIMS: The adult mammalian heart possesses severely limited regenerative capacity. Cardiomyocyte loss during cardiac injury, coupled with this restricted regenerative potential, represents a fundamental cause of heart failure and associated mortality.…
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