Cardiovascular research
Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction.
Yingxi Li, Razoan Al Rimon, Faqi Wang, Haoyang Li, Slava Epelman, Michelle D Tallquist, Lindsey Westover, Gavin Y Oudit, Zamaneh Kassiri
Published: 202610.1093/cvr/cvaf256
Abstract
AIMS: Myocardial infarction (MI) triggers a complex remodeling that, if uncontrolled, leads to heart failure. Increased levels of ADAM17 (disintegrin and metalloproteinase-17) in ischemic injury has been reported, but its direct role in scar formatio…
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