Clinical chemistry
Validation of a Multiplex mRNA- and gDNA-Based Droplet Digital PCR Assay in Acute Myeloid Leukemia Patients with an NPM1 Mutation.
Albertus T J Wierenga, Lucy B Hesp, Arjan Simpelaar, Linde M Morsink, Carolien M Woolthuis, Jan Jacob Schuringa, Isidor Minovic, Gerwin Huls, André B Mulder
Published: 202510.1093/clinchem/hvaf142
Abstract
BACKGROUND: NPM1 is a disease-defining gene in the diagnosis of acute myeloid leukemia (AML) and is important for measurable residual disease (MRD) assessment. Over 50 different NPM1 mutations have been described, but only the 3 most common are routi…
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