Brain : a journal of neurology
ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner.
Anna Steward, Anna Dewenter, Fabian Hirsch, Sebastian N Roemer-Cassiano, Zeyu Zhu, Amir Dehsarvi, Davina Biel, Madleen Klonowski, Lukas Frontzkowski, Carla Palleis, Johannes Gnörich, Martin Dichgans, Günter Höglinger, Matthias Brendel, Nicolai Franzmeier
Published: 202510.1093/brain/awaf463
Abstract
In Alzheimer's disease, carriage of the ApoE4 risk allele is linked to faster tau accumulation at lower amyloid-PET levels, thereby accelerating disease progression. However, it remains unclear whether this ApoE4-facilitated transition from amyloidos…
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