Brain : a journal of neurology
SUR1-TRPM4 is expressed in human epilepsy and promotes neuron hyperactivity and seizures in rodents.
Mitchell B Moyer, Svetlana Ivanova, Kaspar Keledijan, Matthew Kreinbrink, Jenna Langbein, Penghua Yang, Darrian McAfee, Ujwal Boddeti, Ziam Khan, Jemima Owotade, Timothy Zhang, David R Benavides, Joshua Diamond, Kareem Zaghloul, Muznabanu Bachani
Published: 202510.1093/brain/awaf435
Abstract
One third of epilepsy patients do not achieve sufficient seizure freedom with current standard anti-seizure medications. Better understanding of the pathological mechanisms contributing to epileptogenesis is thus necessary to improve current therapie…
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