Brain : a journal of neurology
Single-nucleus multiome shows motor neuron glutamate overactivation in amyotrophic lateral sclerosis.
Eriko Takeuchi, Yoshiaki Yasumizu, Junko Morita, Masakazu Ishikawa, Kotaro Ogawa, Daisuke Motooka, Daisuke Okuzaki, Miho Nagata, Yasuki Ishihara, Yohei Miyashita, Yoshihiro Asano, Kohji Mori, Eiichi Morii, Goichi Beck, Yuko Saito
Published: 202510.1093/brain/awaf426
Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes motor neuron degeneration. However, the mechanisms underlying the selective vulnerability of motor neurons and the involvement of non-motor neuron cells in ALS remain uncl…
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