Brain : a journal of neurology
IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology.
Gianvito Masi, Kangzhi Chen, Alexandra C Bayer, Rafael Bayarri-Olmos, Minh C Pham, Annabel Wallace, Silvia Falso, Amelia Evoli, Raffaele Iorio, Kenneth B Hoehn, Akiko Iwasaki, Richard J Nowak, Kevin C O'Connor
Published: 202510.1093/brain/awaf410
Abstract
Patients with muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG) develop muscle weakness due to functionally monovalent IgG4 autoantibodies (Abs) that target MuSK and disrupt acetylcholine receptor (AChR) clustering. Emerging evidence from…
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