Brain : a journal of neurology
KIF2A downregulation links amyloid-β to Tau phosphorylation in Alzheimer's disease.
Nuria Ruiz-Reig, Margaux Virosztek, Georges Chehade, Nuria Suelves, Nathalie Kyalu Ngoie Zola, Yasmine Salman, Olivier Schakman, Pascal Kienlen-Campard, Bernard Hanseeuw, Fadel Tissir
Published: 202510.1093/brain/awaf382
Abstract
Microtubules (MT) are essential components of the cytoskeleton. Dysfunctions of MT and MT-associated proteins are prominent features of neurodegenerative disorders. In Alzheimer's disease (AD), changes in MT composition and hyperphosphorylation of Ta…
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